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Journal: Bioactive Materials
Article Title: Gynostemma pentaphyllum -derived extracellular vesicles alleviate skin aging by destabilizing STING
doi: 10.1016/j.bioactmat.2026.03.010
Figure Lengend Snippet: The extraction process and proposed mechanisms for GPEVs in treating UVB-induced Skin aging. Extracellular vesicles derived from Gynostemma pentaphyllum (GPEVs), isolated and purified from fresh whole herb via differential ultracentrifugation, exhibit anti-photoaging properties. UVB radiation triggers the up-regulation of STING, activating the TBK1-CTCF pathway and causing photoaging. GPEVs effectively promote STING degradation, reducing CTCF-mediated aging gene transcription, protecting against UVB-induced skin aging.
Article Snippet: The UVB radiation source consists of four
Techniques: Extraction, Derivative Assay, Isolation, Purification